Oct. 29th 2025
Our review paper was published in ChemBioChem. Light-triggered bond cleavage has become a powerful strategy for spatiotemporal control of biomolecular functions. In this concept review, we present a conceptual framework that unifies three major molecular modalities—proteins, small molecules, and metal complexes—to understand and design next-generation photocleavable systems for cell biology. By systematically comparing their design principles, biological applicability, and remaining challenges, we highlight how these modalities can be optimized to balance functionality, biocompatibility, and optical responsiveness. This cross-disciplinary perspective aims to guide the development of versatile and practical photoresponsive tools that enable precise control of molecular events in living systems.
M.Yoshimura,* T. Inose,* “Photocleavable Systems for Cell Biology: Conceptual Design across Molecular Modalities“, ChemBioChem., 2025, e202500564. DOI: 10.1002/cbic.202500564.
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