New ACIE Publication: A Molecular Design for Efficient Protein Release

Apr. 28^th 2025

Our collaboration paper with Prof. Tomoko Inose was published in Angewandte Chemie International Edition. In this work, we developed a new coumarin-based photocleavable molecule that features both enhanced hydrolytic stability and superior photo-stimulated bond cleavage. The design enables efficient light-triggered protein release and holds promise as a new tool for chemical biology and intracellular manipulation.

M.Yoshimura,* R. Sasayama, T. Kajiwara, C. Mori, Y. Nakasone, T. Inose,* “Effect of Remote Silyl Groups on the Hydrolytic Stability and Rapid Photocleavage of Carbamates“, Angew. Chem. Int. Ed., 2025, e202502376. DOI: 10.1002/anie.202502376.